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Laboratorio de Bioprocesos

Somos un equipo integral en busca de desarrollar soluciones innovadoras para la producción, degradación y aplicación de polímeros naturales / sintéticos, con bases biotecnológicas sostenibles con potencial de transferencia tecnológica.

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Publicaciones

  • Guajardo, C., Rojas, J., Baldera-Moreno, Y., Adasme-Carreño, F., Kasai, D., Andler, R. 2025. New insights on poly(cis-1,4-isoprene) rubber degradation through enzymatic kinetics and process improvement. Frontiers in Bioengineering and Biotechnology 13:1593339.
  • Andler, R., Cancino, C., González-Arancibia, F., Rojas, J., Castro, R., Kasai, D., Sanhueza, V. 2025. Bio-desulfurization of different vulcanized rubber blends: An ecofriendly approach for end-of-life tires waste pollution. Journal of Environmental Chemical Engineering 13,
  • Tamamura, M., Gibu, N., Toda, T., Takenaka, K., Hang, D.T., Huong, N.L., Andler, R., Kasai, D. 2024. Characterization of the conversion system of natural rubber to poly (3-Hydroxyalkanoate) in Piscinibacter gummiphilus strain NS21. New Biotechnology 84, 1-8.
  • González-Arancibia, F., Mamani, M., Valdés, C., Contreras-Matté, C., Pérez, E., Aguilera, J., Rojas, V., Ramirez-Malule, H., Andler, R. 2024. Biopolymers as Sustainable and Active Packaging Materials: Fundamentals and Mechanisms of Antifungal Activities. Biomolecules 14, 1224.
  • Guajardo, C., Andler, R. 2024. Challenges and perspectives in enzymatic polymer fragmentation: The case of rubber and polyethylene terephthalate. Journal of Cleaner Production 450, 141875.
  • Andler, R., González-Arancibia, F., Vilos, C., Sepulveda-Verdugo, R., Castro, R., Mamani, M., Valdés, C., Arto-Paz, F., Díaz-Barrera, A., Martínez, I. 2024. Production of poly-3-hydroxybutyrate (PHB) nanoparticles using grape residues as the sole carbon source. International Journal of Biological Macromolecules 261, 129649.
  • Valdés, C., Quispe, C., Fritz, R.A., Andler, R., Villaseñor, J., Pecchi, G., Avendaño, E., Delgadillo, A., Setzer, W.N., Sharifi-Rad, J. 2024. MnO2/TiO2-catalyzed ozonolysis: enhancing Pentachlorophenol degradation and understanding intermediates. BMC Chemistry 18:83.
  • Baldera-Moreno, Y., Hernández, C., Vargas, A., Rojas-Palma, A., Morales-Vera, R., Andler, R. 2024. Effects of turning aeration and initial carbon/nitrogen ratio on the biodegradation of polylactic acid under controlled conditions. International Journal of Biological Macromolecules 268, 131689.
  • Urtuvia, V., Ponce, B., Andler, R., Díaz-Barrera, A. 2023. Relation of 3HV fraction and thermomechanical properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Azotobacter vinelandii International Journal of Biological Macromolecules 253, 127681.
  • Andler, R., Rojas, V., Pino, V., Castro, R.I., Valdés, C., Kumar, V., Peña, C., Díaz-Barrera, A. 2023. Efficient production of a polyhydroxyalkanoate by Azotobacter vinelandii OP using apple residues as promising feedstock. International Journal of Biological Macromolecules 242, 124626.
  • Baldera-Moreno, Y., Rojas-Palma, A., Andler, R., Cuesta-Herrera, L. 2023 Mathematical model of polylactic acid biodegradation under controlled composting conditions. Journal of Physics: Conference Series 2515, 012004.
  • Andler, R., Guajardo, C., Sepúlveda, C., Pino, V., Sanhueza, V., D’Afonseca, V. Biodegradation of rubber in cultures of Rhodococcus rhodochrous and by its enzyme latex clearing protein. Biodegradation 33, 609-620.
  • Urtuvia, V., Ponce, B., Andler, R., Peña, C., Diaz-Barrera, A. Extended batch cultures for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) production by Azotobacter vinelandii OP growing at different aeration rates. 3-Biotech 12, 304.
  • Andler, R., Tiso, T., Blank, L., Andreessen, C., Zampolli, J., Guajardo, C., Díaz-Barrera, A. Current progress on the biodegradation of synthetic plastics: from fundamentals to biotechnological applications. Reviews in Environmental Science and Biotechnology 21, 829-850.
  • Baldera-Moreno, Y., Pino, V., Farres, A., Banerjee, A., Gordillo, F., Andler, R. 2022. Biotechnological aspects and mathematical modeling of the biodegradation of plastics under controlled conditions. Polymers 14, 375.
  • Andler, R., D’Afonseca, V., Pino, J., Valdés, C., Salazar-Viedma, M. 2021. Assessing the biodegradation of vulcanized rubber particles by fungi using genetic, molecular and surface analysis. Frontiers in Bioengineering and Biotechnology 9: 761510.
  • Valdés, C., Hernández, C., Morales-Vera, R., Andler, R. 2021. Desulfurization of vulcanized rubber particles using biological and couple microwave-chemical methods. Frontiers in Environmental Science 9: 633165.
  • Andler, R., Valdés, C., Urtuvia, V., Andreeßen, C., Díaz-Barrera, A. 2021. Fruit residues as a sustainable feedstock for the production of bacterial polyhydroxyalkanoates. Journal of Cleaner Production 307: 127236.
  • Andler, R., Pino, V., Moya, F., Soto, E., Valdés, C., Andreeßen, C. 2021. Synthesis of poly-3-hydroxybutyrate (PHB) by Bacillus cereus using grape residues as sole carbon source. International Journal of Biobased Plastics 3: 98-111.
  • Díaz-Barrera, A., Sanchez-Rosales, F., Padilla-Córdova, C., Andler, R., Peña, C. 2021. Molecular weight and guluronic/mannuronic ratio of alginate produced by Azotobacter vinelandii at two bioreactor scales under diazotrophic conditions. Bioprocess and Biosystems Engineering 44, 1275-1287.
  • Andler, R., 2020. Bacterial and enzymatic degradation of poly(cis-1,4-isoprene) rubber: Novel biotechnological applications. Biotechnology Advances 44: 107606.
  • Andler, R., Valdés, C., Díaz-Barrera, A., Steinbüchel, A. 2020. Biotransformation of poly(cis-1,4-isoprene) in a multiphase enzymatic reactor for continuous extraction of oligo-isoprenoid molecules. New Biotechnology 58: 10-16.
  • Andler, R., Heger, F., Andreessen, C., Steinbüchel, A. 2019. Enhancing the synthesis of latex clearing protein by different cultivation strategies. Journal of Biotechnology 297: 32-40.
  • Vivod, R., Andler. R., Oetermann, S., Altenhoff, A-L., Seipel, N., Holtkamp, M., Hogeback, J., Karst, U., Steinbüchel, A. 2019. Characterization of the latex clearing protein of the poly(cis-1,4-isoprene) and poly(trans-1,4-isoprene) degrading bacterium Nocardia nova SH22a. The Journal of General and applied Microbiology 65: 293-300.
  • Andler R., Vivod R., Steinbüchel A. 2019. Synthesis of polyhydroxyalkanoates through the biodegradation of poly(cis-1,4-isoprene) rubber. Journal of Bioscience and Bioengineering 127: 360-365.
  • Altenhoff L., de Witt J., Andler R., Steinbüchel A. 2019. Impact of additives of commercial rubber compounds on the microbial and enzymatic degradation of poly(cis-1,4-isoprene). Biodegradation 30: 13-26.
  • Andler R., Altenhoff A.-L., Mäsing F., Steinbüchel A. 2018. In vitro studies on the degradation of poly(cis-1,4-isoprene). Biotechnology Progress 34: 890-899.
  • Andler R., Hiessl S., Yücel O., Tesch M., Steinbüchel A. Cleavage of poly(cis-1,4-isoprene) rubber particles by cultures of Gordonia polyisoprenivorans. New Biotechnology 44: 6-12.
  • Andler R., Steinbüchel A. 2017. A simple, rapid and cost-effective process for production of latex clearing protein to produce oligopolyisoprene molecules. Journal of Biotechnology 241: 184-192.
  • Díaz-Barrera A., Andler R., Martínez I., Peña C. 2016. Poly-3-hydroxybutyrate production by Azotobacter vinelandii strains in batch cultures at different oxygen transfer rates. Chemical Technology and Biotechnology 91: 1063-1071.

Colaboraciones nacionales/internacionales

Colaboraciones nacionales

  • Pontificia Universidad Católica de Valparaíso. Grupo de investigación del Dr. Alvaro Díaz, Lorena Wilson y Paulina Urrutia de la Escuela de Ingeniería Bioquímica.


Colaboraciones internacionales

  • Nagaoka University of Technology, Japan. Grupo de investigación del Dr. Daisuke Kasai.
  • University of Stuttgart, Alemania. Grupo de investigación del Dr. Dieter Jendrossek.
  • Universidad Complutense de Madrid, España. Grupo de investigación del Dr. Juan Manuel Bolivar.
  • University of Strasbourg, France. Grupo de investigación del Dr. Eric Pollet.
  • University of Applied Sciences Northwestern, Switzerland (FHNW). Grupo de investigación del Dr. Marcel Suleiman.

Proyectos

  • Validación de bio-packaging activo para fruta de exportación. IdeA Investigación Tecnológica IT25I0081. 2026-2028.
  • Biodegradation analysis of different vulcanized rubber blends and main additives in tires. Fondecyt regular N° 1230313. 2023-2027.
  • Bio-packaging en base a aerogel de residuos orgánicos para fruta de exportación. Fondo de Innovación para la Competitividad (FIC) de la región del Maule. Código IDI: 40.047.042-0. 2023-2026.
  • Valorización técnico-económica de los residuos frutícolas como sustrato para la producción de bioplásticos. Fondo de Innovación para la Competitividad (FIC) de la región de O’Higgins. Código IDI:40017923-0. 2019-2022.
  • A multi-stage bioprocess for rubber biodegradation. Fondecyt Iniciación N° 11190220. 2019-2022.

Contratos tecnológicos

  • Research on recycling vulcanized rubber based on desulfurization by biodegradation.
    Empresa: Yokohama Rubber, Japan
    Universidad: Nagaoka University of Technology, Japan y Universidad Católica del Maule
  • Biodegradation studies on different rubber blends
    Empresa Carbios, France
    Universidad: Universidad Católica del Maule
    2022-2023
  • Production and characterization of rubber oxygenases
    Empresa: Carbios, France
    Universidad: University of Stuttgart, Germany
     2021-2022