Whitney C. Venturini Méndez

Departamento de Ciencias Preclínicas, Facultad de Medicina UCM

Línea de investigación: El rol de canales iónicos en cáncer, proponiendo este tipo de canales como candidatos potenciales para el diagnóstico y la investigación de la enfermedad.  Efecto del fenotipo secretor asociado a senescencia de células endoteliales en la función plaquetaria y su influencia en procesos trombóticos.

Grado académico:

• Químico Farmacéutico, Universidad Santa María Venezuela
• Doctor en Ciencias Biomédicas, Universidad de Talca

Publicaciones Relevantes

• Camargo-Ayala L, Bedoya M, Dasí A, Prüser M, Schütte S, Prent-Peñaloza L, Adasme-Carreño F, Kiper AK, Rinné S, Camargo-Ayala P, Peña-Martínez PA, Bueno-Orovio A, Varela D, Wiedmann F, Márquez-Montesinos JCE, Mazola Y, Venturini W, et al. (2025). Rational Design, Synthesis, and Evaluation of Novel Polypharmacological Compounds Targeting NaV1.5, KV1.5, and K2P Channels for Atrial Fibrillation.Journal of Biological Chemistry, 108387.
• Forero-Doria O, Guzmán L, Venturini W, Zapata F, Duarte Y, Camargo-Ayala L, Echeverría J. (2024). O-alkyl derivatives of ferulic and syringic acid as lipophilic antioxidants… RSC Advances.
• Cayo A, Venturini W, Rebolledo-Mira D, Moore-Carrasco R, Herrada AA, Nova-Lamperti E, Valenzuela C, Brown NE. (2023). Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy. Int J Mol Sci, 24(11):9284.
• Forero-Doria O, Parra-Cid C, Venturini W, Espinoza C, Araya-Maturana R, Valenzuela-Riffo F, Saldias C, Leiva A, Duarte Y, Echeverría J, Guzmán L. (2022). Novel N-benzoylimidazolium Ionic Liquids Derived from Benzoic and Hydroxybenzoic Acids as Therapeutic Alternative Against Biofilm-forming Bacteria. Bioorganic Chemistry, 105914.
• Huilcaman R, Venturini W, Fuenzalida L, Cayo A, Segovia R, Valenzuela C, Brown N, Moore-Carrasco R. (2022). Platelets, a Key Cell in Inflammation and Atherosclerosis Progression. Cells, 11(6):1014.
• Cayo A, Segovia R, Venturini W, Moore-Carrasco R, Valenzuela C, Brown N. (2021). mTOR activity and autophagy in senescent cells, a complex partnership. Int J Mol Sci, 22(15):8149.
• Huilcaman R, Veliz-Olivos N, Venturini W, Olate-Briones A, Treuer AV, Valenzuela C, Moore-Carrasco R. (2021). Endothelial transmigration of platelets depends on soluble factors released by activated endothelial cells and monocytes. Platelets, 1-7.
• Venturini W, Olate-Briones A, Valenzuela C, Méndez D, Fuentes E, Cayo A, Mancilla D, Segovia R, Brown NE, Moore-Carrasco R. (2020). Platelet activation is triggered by factors secreted by senescent endothelial HMEC-1 cells in vitro. Int J Mol Sci, 21(9):3287.
• Guzmán L, Nerio LS, Venturini W, Macias JP, Donoso W, Forero-Doria O. (2020). Antiplatelet and antibacterial activities of Essential Oils obtained from rhizomes and leaves of Hedychium coronarium. Anais Acad Bras Ciênc, 92(2).
• Valenzuela CA, Quintanilla R, Olate-Briones A, Venturini W, Mancilla D, Cayo A, Moore-Carrasco R, Brown NE. (2019). SASP-dependent interactions between senescent cells and platelets modulate migration and invasion of cancer cells. Int J Mol Sci, 20(21):5292.
• Bruges G, Venturini W, Crespo G, Zambrano ML. (2018). Pyrogallol induces apoptosis in human platelets. Folia Biol, 64(1):23–30.
• Estrada O, Contreras W, Acha G, Lucena E, Venturini W, Cardozo A, Alvarado-Castillo C. (2014). Chemical constituents from Licania cruegeriana and their cardiovascular and antiplatelet effects. Molecules, 19(12):21215–21225.

Colaboración activa con el Dr. Leandro Zúñiga (ND3, Universidad de Talca) y participación en redes nacionales e internacionales en farmacología de canales iónicos, química medicinal y biomedicina traslacional.