Jean Paulo de Andrade

Departamento de Medicina Traslacional. Laboratorio de Química y Farmacia – Facultad de Medicina UCM

Línea de investigación: Optimización de métodos de extracción y dereplicación de compuestos derivados de alcaloides de especies chilenas de la familia Amaryllidaceae. Evaluación de los alcaloides de Amaryllidaceae en distintos blancos moleculares asociados a la neuroprotección y a la Enfermedad de Alzheimer. Evaluación biológicos de los alcaloides de Amaryllidaceae en dianas asociadas al cáncer y a la actividad antiparasitaria.

Grado académico:

• Químico Farmacéutico, Universidade Federal do Rio Grande do Sul, Brasil.
• Magíster en Ciencias Farmacéuticas, Universidade Federal do Rio Grande do Sul, Brasil.
• Máster en Ciencias Farmacéuticas, Universidad de Barcelona, España.
• Doctorado en Ciencias Farmacéuticas, Universidad de Barcelona, España.

Publicaciones y Artículos:

• HERNANDEZ, R.E., DE ANDRADE, J.P., OPAZO, N., CASTILLO, I., BERKOV, S., ARENCIBIA, A.D., (2025) Effective in vitro bulbification and alkaloid dereplication by GC-MS of Chilean Zephyranthes splendens, an endemic species of the Andes mountains, Plant Cell, Tissue and Organ Culture, 162:49, doi: 10.1007/s11240-025-03152-w.  
• BESSA, C.D.P.B., FEU, A.E., DE MENEZES, R.P.B., SCOTII, M.T., LIMA, J.M.G., LIMA, M.L., TEMPONE, A.G., DE ANDRADE, J.P., BASTIDA, J., BORGES, W.S.*, (2024) Multitarget anti-parasitic activities of isoquinoline alkaloids isolated from Hippeastrum aulicum (Amaryllidaceae), Phytomedicine, 128, 155414, doi: 10.1016/j.phymed.2024.155414 
• ROSA, M., DE ANDRADE, J.P., COSTA. A.O., CONTI, R., BASTIDA, J., BORGES, W.S., FURST, C.* (2022). Anti-Acanthamoeba castellanii activity of alkaloid-enriched extracts and lycorine from the Amaryllidaceae species. Brazilian Journal of Pharmaceutical Science, 58:e20459, doi: 10.1590/s2175-97902022e20459. 
• SIERRA, K., DE ANDRADE, J.P., TALLINI, L.R., OSORIO, E. H., YAÑÉZ, O., OSORIO, M.I., OLEAS, N.H., GARCÍA-BELTRÁN, O., BORGES, W.S., BASTIDA, J., OSORIO, E.*, CORTES, N. (2022). In vitro and in silico analysis of galanthine from Zephyranthes carinata as an inhibitor of acetylcholinesterase. Biomedicine & Pharmacotheraphy, 150, 113016, doi: 10.1016/j.biopha.2022.113016. 
• SOPRANI, L.C., DE ANDRADE, J.P., DOS SANTOS, V.D., ALVES-ARAUJO, A., BASTIDA, J., GASCA-SILVA, C.A., SILVEIRA, D., BORGES, W.S., JAMAL, C.M.* (2021) Chemical evaluation and anticholinesterase activity of Hippeastrum puniceum (Lam.) Kuntz bulbs (Amaryllidaceae). Brazilian Journal of Pharmaceutical Science, 57: e19154, doi: 10.1590/s2175-97902020000419154 
• TALLINI, R.L, GIORDANI, R.B., DE ANDRADE, J.P., BASTIDA, J., ZUANAZZI, J.A.S.* (2021). Structural Diversity and Biological Potential of Alkaloids from the Genus Hippeastrum, Amaryllidaceae: An Update. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, doi: 10.1007/s43450-021-00211-z 
• SHAWKY, E.*, SOHAFY, S.M.E., DE ANDRADE, J.P., BORGES, W.S. (2021). Profiling of acetylcholinesterase inhibitory alkaloids from some Crinum, Habranthus and Zephyranthes species by GC–MS combined with multivariate analyses and in silico studies. Natural Product Research, doi: 10.1080/14786419.2019.1598989. 
• FEU, A.E., DE ANDRADE, J.P.*, AYALA, A.P., DE ALMEIDA, L.C., COSTA-LOTUFO, L.V., BASTIDA, J., ELLENA, J., BORGES, W.S. (2021) Glycosylated narciclasine alkaloid in Hippeastrum puniceum (Lam). Kuntze. South African Journal of Botany, 136, 30-34. 
• SCHMEDA-HIRSCHMANN, G.*, DE ANDRADE, J.P., JIMÉNEZ-ASPEE, F., CASTRO-MIERES, D., (2020) A cyclic dipeptide from the Chilean hazelnut cotyledons (Gevuina avellana Mol., Proteaceae), Scientific Reports, 10, 7070, doi: 10.1038/s41598-020-63983-9. 
• LIANZA, M., VERDAN, M.H., DE ANDRADE, J.P., POLI, F., DE ALMEIDA, L.C., COSTA-LATUFO, L., NETO, A.C., OLIVEIRA, S.C.C., BASTIDA, J., BATISTA, A.N.L., BATISTA Jr, J.M., BORGES, W.S.*, (2020) Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae), Journal of the Brazilian Chemical Society, 31(10), 2135-45, doi: 10.21577/0103-5053.20200116. 
• DE ALMEIDA, W.A.M., DE ANDRADE, J.P., CHACON, D.S., LUCAS, C.R., MARIANA, E., FERREIRA, L.S., GUARATINI, T., BARBOSA, E.G., ZUANAZZI, J.A.S., HALLWASS, F., BORGES, W.S., OLIVEIRA, R.P., GIORDANI, R.B.*, (2020) Isoquinoline alkaloids reduce beta-amyloid peptide toxicity in Caenorhabditis elegans. Natural Products Research, doi: 10.1080/14786419.2020.1727471. 
• SCHMEDA-HIRSCHMANN, G., DE ANDRADE, J.P., SOTO-VASQUEZ, M.R., ALVARADO-GARCÍA, P.A.A., PALOMINOS, C., FUENTES-RETAMAL, C., MELLADO, M., CORREA, P., URRA, F.A.*, (2020) The parotoid gland secretion from Peruvian toad Rhinella horribilis (Wiegmann, 1833): chemical composition and effect on the proliferation and migration of lung cancer cells. Toxins, 12, 608, doi: 10.3390/toxins12090608. 
• COLE, E.R., DE ANDRADE, J.P., FILHO, J.F.A., SCHMITT, E.F.P., ALVES-ARAÚJO, A., BASTIDA, J., ENDRINGER, D., BORGES, W.S., LACERDA Jr, V., (2019) Cytotoxic and genotoxic activities of alkaloids from the bulbs of Griffinia gardneriana and Habranthus itaobinus (Amaryllidaceae), Anti-Cancer Agents in Medicinal Chemistry, 
• GONRING-SALARINI, K.L., CONTI, R., DE ANDRADE, J.P., BORGES, B.J.P., AGUIAR, A.C.C., DE SOUZA, J.O., ZANINI, C.L., OLIVA, G., TENORIO, J.C., ELLENA, J., BASTIDA, J., GUIDO, R.V.C., BORGES, W.S.*, (2019) In vitro antiplasmodial activities of alkaloids isolated from the roots of Worsleya procera (Lem.) Traub (Amaryllidaceae), Journal of the Brazilian Chemical Society, doi: /10.21577/0103-5053.20190061.  
• TALLINI, L. R., DE ANDRADE, J.P., KAISER, M., VILADOMAT, F., NAIR, J. J., ZUANAZZI, J.A.S., BASTIDA, J.*, (2017) Alkaloid Constituents of the Amaryllidaceae Plant Amaryllis belladonna L, Molecules, 22, 1437, doi: 10.3390/molecules22091437. 
• GALVAO, D.C. MORAES, C.T., BORGES, B.J.P., CARDOSO, W.C., DE ANDRADE, J.P., TAKAHASHI, P.M., VIEIRA, P.C., BORGES, W.S.*, (2017) Secondary metabolites from Pachystroma longifolium (Ness) I. M. Johnst (Euphorbiaceae) and evaluation of its extracts as cathepsins inhibitors, Journal of the Chilean Chemical Society, 62, 3. 
• GUERRIERI, C.G., PIGNI, N.B., DE ANDRADE, J.P., DOS SANTOS, V.D., BINNS, F., DE SOUZA, B.W., VILADOMAT, F., BASTIDA, J.*, (2016) Alkaloids from Crinum erubescens Aiton, Arabian Journal of Chemistry, doi: 10.1016/j.arabjc.2015.07.009. 
• BESSA, C., DE ANDRADE, J.P., DE OLIVEIRA, R., DOMINGOS, E., SANTOS, H., ROMÃO, W., BASTIDA, J., BORGES, W.*, (2016) Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb. (Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS-MS and LS-MS), Journal of the Brazilian Chemical Society, 28(5), 819-30. 
• KLEIN-JUNIOR, L. C.; PASSOS, C. S.; SALTON, J.; BITENCOURT, F. G.; FUNEZ, L.; DE ANDRADE, J. P.; VILLALOBOS, J. P.; BORDIGNON, S. A. L.; GASPER, A. L.; HEYDEN, Y. V.; HENRIQUES, A. T., (2016) Multifunctional Monoamine Oxidases and Cholinesterases Inhibitory Effects, as well as UPLC-DAD-MS Chemical Profile of Alkaloid Fractions Obtained from Species of the Palicoureeae Tribe, Natural Products Communications, 11(9), 1271-74. 
• GUO, Y., DE ANDRADE, J.P., PIGNI, N.B., TORRAS-CLAVERIA, L., TALLINI, L.R., BORGES, W.S., VILADOMAT, F., NAIR, J.J., ZUANAZZI, J.A.S., BASTIDA, J.*, (2016) New Alkaloids from Hippeastrum papilio (Ravenna) Van Scheepen, Helvetica Chimica Acta, 99, 143-47. 
• DE ANDRADE, J.P., GIORDANI, R.B., TORRAS-CLAVERIA, L., PIGNI, N.B., BERKOV, S., FONT-BARDIA, M., CALVET, T., KONRATH, E., BUENO, K., SACHETT, L.G., DUTILH, J.H., DE SOUZA, B.W., VILADOMAT, F., HENRIQUES, A.T., NAIR, J.J., ZUANAZZI, J.A.S., BASTIDA, J.*, (2016) The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids, Phytochemistry Reviews, 15, 147-60. 
• SEBBEN, C., GIORDANI, R.B., DE ANDRADE, J.P., BERKOV, S., OSORIO, E.J., SOBRAL, M., DE ALMEIDA, M.V., HENRIQUES, A.T., BASTIDA, J., ZUANAZZI, J.A.S.*, (2015) New lycosinine derivative from Hippeastrum breviflorum, Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 25, 353-55. 
• GUO, Y.; PIGNI, N.B., ZHENG, Y.; DE ANDRADE, J.P., TORRAS-CLAVERIA, L., BORGES, W. S., VILADOMAT, F., CODINA, C., BASTIDA, J.*, (2014) Analysis of Bioactive Amaryllidaceae Alkaloid Profiles in Lycoris Species by GC-MS, Natural Products Communications, 9(8), 1081-86. 
• DE ANDRADE, J.P., GUO, Y., FONT-BARDIA, M., CALVET, T., DUTILH, J.H., VILADOMAT, F., CODINA, C., NAIR, J.J.; ZUANAZZI, J.A.S., BASTIDA, J.*, (2014) Crinine-type alkaloids from Hippeastrum aulicum and H. calyptratum, Phytochemistry, 103, 188-95. 
• IANELLO, C., PIGNI, N.B, ANTOGNONI, F., POLI, F., MAXIA A., DE ANDRADE, J.P., BASTIDA, J.*, (2014) A potent acetylcholinesterase inhibitor from Pancratium illyricum L., Fitoterapia, 92, 163-67. 
• DE ANDRADE, J. P., PIGNI, N. B., TORRAS-CLAVERIA, L., GUO, Y., BERKOV, S., REYES-CHILPA, R., AMRANI, A. E., ZUANAZZI, J.A.S., CODINA, C., VILADOMAT, F., Bastida, J., (2012) Alkaloids from the Hippeastrum genus: chemistry and biological activity. Revista Latinoamericana de Química, 40, p.83. 
• DE ANDRADE, J.P., PIGNI, N.B., TORRAS-CLAVERIA, L., BERKOV, S., CODINA, C., VILADOMAT, F., BASTIDA, J.*, (2012) Bioactive alkaloid extracts from Narcissus broussonetii: Mass spectral studies. Journal of Pharmaceutical and Biomedical Analysis,70, 13 – 25. 
• GIORDANI, R.B., JUNIOR, C.O.R., DE ANDRADE, J. P., BASTIDA, J., ZUANAZZI, J.A.S., TASCA, T., DE ALMEIDA, M.V.*, (2012) Lycorine Derivatives Against Trichomonas vaginalis. Chemical Biology & Drug Design (Print). v.80, p.129 – 133. 
• BASTIDA, J., BERKOV, S., TORRAS-CLAVERIA, L., PIGNI, N.B., DE ANDRADE, J. P., MARTINEZ, V., CODINA, C., VILADOMAT, F. In: Recent Advances in Pharmaceutical Sciences, ed.2. Kerala: Transworld Research Network, 2011, p. 65 – 100. 
• DE ANDRADE, J.P., BERKOV, S., VILADOMAT, F., CODINA, C., ZUANAZZI, J.A.S., BASTIDA, J.*, (2011) Alkaloids from Hippeastrum papilio. Molecules, 16, 7097 - 7104. 
• GIORDANI, R.B., DE ANDRADE, J.P., VERLI, H., DUTILH, J.H., HENRIQUES, A.T., BERKOV, S., BASTIDA, J., ZUANAZZI, J.A.S.*, (2011) Alkaloids from Hippeastrum morelianum Lem. (Amaryllidaceae), (2011) Magnetic Resonance in Chemistry, 49, 668 – 672. 
• Pagliosa, L.B.; Monteiro, S.C.; Silva, K.B.; DE ANDRADE, J.P.; Dutilh, J.; Bastida, J.; Cammarota, M.; Zuanazzi, J.A.S., (2010) Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. Phytomedicine (Stuttgart). v.17, p.698 – 701. 
• SILVA, A; DE ANDRADE, J. P.; MACHADO, K; ROCHA, A; APEL, M; SOBRAL, M; HENRIQUES, A; ZUANAZZI, J., (2008) Screening for cytotoxic activity of extracts and isolated alkaloids from bulbs of Hippeastrum vittatum. Phytomedicine, 15, 882 – 885. 
• DASILVA, A; DE ANDRADE, J. P.; BEVILAQUA, L; DESOUZA, M; IZQUIERDO, I; HENRIQUES, A; ZUANAZZI, J., (2006) Anxiolytic-, antidepressant- and anticonvulsant-like effects of the alkaloid montanine isolated from Hippeastrum vittatum. Pharmacology, Biochemistry and Behavior, 85, 148 – 154