Ingrid V. Carvacho Contreras

Grado académico:

• Bioquímico, Universidad de Concepción
• Doctora en Ciencias Mención en Biología Celular y Molecular, Universidad Austral de Chile
• Postdoctorado en Canales de calcio, Boston Children’s Hospital, Harvard Medical School
• Postdoctorado en Biología Reproductiva, Universidad de Aarhus Dinamarca

Departamento de Medicina Traslacional. Laboratorio de Canales Iónicos y Reproducción – Facultad de Medicina UCM

Línea de investigación: Función de canales de iones en fertilización y desarrollo embrionario temprano.  Biofísica de canales iónicos. Farmacología de canales iónicos.

Publicaciones Relevantes

• Lopes EM, Akizawa H, Koc OC, Soto-Moreno E, Gupta N, Ardestani G, Balboula AZ, Carvacho I, Fissore RA. 2025. “The TRPV3 Channel is a Novel Mediator of Zinc Influx and Homeostasis in Murine Oocytes”. Proceedings of the National Academy of Sciences of the United States of America, PNAS. Vol. 122, n° 14 e2420194122. PMID: 40168130. 
• García-Castro P, Giambó-Falian I, Carvacho I&, Fuentes R&. 2025. “Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition”. Frontiers in Cell & Developmental Biology. Jan 30;13:1514461. &: corresponding author. PMID: 39949602 

•    Suárez-Suárez C, González-Pérez S, Márquez-Miranda V, Araya-Duran I, Vidal-Beltrán I, Vergara S, Carvacho I, Hinostroza F. 2024. “The Endocannabinoid Peptide RVD-Hemopressin Is a TRPV1 Channel Blocker”. Biomolecules. Sep 8;14(9):1134. PMID: 39334900. 

•    Gupta N, Soriano- Úbeda C, Stein P, Savy V, Papas BN, Ardestani G, Carvacho I, Alfandari D, Williams CJ, Fissore RA. 2023. “Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme deficient gametes”. Cell Reports. Vol. 42, 113232, October 31, 2023. PMID: 37824328. 

•    Ochoa SV, Otero L, Aristizabal-Pachon AF, Hinostroza F, Carvacho I, Torres YP. 2021. “Hypoxic Regulation of the Large- Conductance Calcium and Voltage-Activated Potassium Channel, BK”. Frontiers in Physiology. Dec. 2021, Vol.12, article 780206. DOI: https://doi.org/10.3389/fphys.2021.780206 

•    Rojas J, Hinostroza F, Vergara S, Pinto-Borguero I, Aguilera F, Fuentes R&, Carvacho I&. 2021. “Knockin´on Egg´s door: Maternal control of egg activation that influences cortical granule exocytosis in animal species”. Frontiers in Cell & Developmental Biology. Sep 3;9:704867. PMID: 34540828. &: corresponding author. 

•    Mehregan A, Ardestani G, Akizawa H, Carvacho I, Fissore R. 2021. “Deletion of TRPV3 and CaV3.2 T-type channels in mice undermines fertility and Ca2+ homeostasis in oocytes and eggs”. Journal of Cell. Sci. Jul 1;134(13):jcs257956. PMID: 34313315. 

•    Carvacho I & Piesche M. 2021 “RGD-binding integrins and TGF-β in SARS-CoV-2 infections - novel targets to treat COVID-19 patients?”. Clinical & Translational Immunology. Mar 18;10(3):e1240. PMID: 33747508. 

•    Henao JC, Grismaldo A, Barreto A, Rodríguez- Pardo VM, Mejía-Cruz CC, Leal-García E, Pérez-Nuñez R, Rojas P, Latorre R, Carvacho I, Torres YP. 2021. “TRPM8 Channel Promotes the Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells”. Frontiers in Cell & Developmental Biology. Feb 4;9:592946. PMID: 33614639. 

•    Tadich TA, de Freslón I, Gallo C, Zúñiga JM, Vargas R, Torres CG, Tadich N, Gimpel J, Martinez C, Sandoval D, Enríquez R, Alfaro J, Muñoz P, Paredes R, Erranz B, Carvacho I, Mezzano M, Herrera EA. 2020. “Incorporación de estándares bioéticos para la generación de conocimiento científico de calidad en investigación en fauna silvestre: Ciencia con conciencia”. Aceptado en Gayana. Vol. 84, No. 1, 60-66; https://gayana.cl/index.php/gn (págs en el artículo: 68-74). 

•    Ardestani G, Mehregan A, Fleig A, Horgen FD, Carvacho I, Fissore RA. 2020. “Divalent calcium influx and calcium homeostasis in germinal vesicle mouse oocytes”. Cell Calcium. Vol.87, May 2020. PMID: 32097818.  

•    Gomez-Mellado A, Munoz T, Paiva C, Vilches K, Carvacho I. 2019. “Entropy production of ion thermo-diffusion in cell membranes”. Journal of Physics: Conference Series. Vol. 1160, conference 1.  

•    Bernhardt ML, Stein P, Carvacho I, Krapp C, Ardestani G, Mehregan A, Umbach DM, Bartolomei MS, Fissore RA, Williams CJ. 2018. ”TRPM7 and Cav3.2 channels mediate Ca2+ influx required for egg activation at fertilization”. Proceedings of the National Academy of Sciences of the United States of America, PNAS. Oct 30;115(44):E10370-E10378. PMID: 30322909. 

•    Carvacho I&, Piesche M, Maier TJ, Machaca K. 2018. “Ion channel function during oocyte maturation and fertilization”. Frontiers in Cell and Developmental Biology. Jun 26;6:63. PMID: 29998105. &: corresponding author 

•    Ramirez D, Gonzalez W, Fissore RA, Carvacho I&. 2017. “Conotoxins as tool to understand the physiological function of voltage-gated calcium (Cav) channels”. &: corresponding author. Marine Drugs. Oct. 13; 15(10). PMID: 29027927. 

•    Comerma-Steffensen SG, Carvacho I, Hedegaard ER, Simonsen U. 2017. ”Small and intermediate calcium-activated potassium channels openers improve rat endothelial and erectile function”. Frontiers in Pharmacology. Sep.20; 8: 660. PMID: 28993731.  

•    Carvacho I&, Ardestani G, Lee HC, McGarvey K, Fissore RA, Lykke-Hartmann K&. 2016. “TRPM7-like channels are functionally expressed in oocytes and modulate post-fertilization embryo development in mouse”. &: corresponding authors. Scientific Reports. Sep. 29; 6:34236. PMID: 27681336. 

•    Lee HC, Yoon SY, Lykke-Hartmann K, Fissore RA&, Carvacho I&. 2016. “TRPV3 channels mediate Ca2+ influx induced by 2-APB in mouse eggs”. &: corresponding authors. Cell Calcium. Jan; 59(1):21-31. PMID: 26725171. 

•    Carvacho I, Lee HC, Fissore RA, Clapham DE. 2013. “TRPV3 channels mediate strontium-induced mouse egg activation”. Cell Reports. Dec. 12; 5(5): 1375-1386. PMID: 24316078. 

•    Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MS, Clapham DE. 2010. “An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1”. Nature Structural and Molecular Biology (NSMB). Jul 17 (7): 869-875. ( contributed equally). PMID: 20543828. 

•    Carvacho I, González W, Torres YP, Brauchi S, Alvarez O, González-Nilo FD, Latorre R. 2008. “Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block”. The Journal of General Physiology (JGP). Vol. 131 (2): 147-161. (* contributed equally). PMID: 18227273. 

•    Torres YP, Morera FJ, Carvacho I, Latorre R. 2007 “A marriage of convenience: b-Subunits and voltage-dependent K+ Channels”. The Journal of Biological Chemistry (JBC). Vol. 282 (34): 24485 – 24489. PMID: 17606609. 

•    Orio P, Torres Y, Rojas P, Carvacho I, Garcia ML, Toro L, Valverde MA, Latorre R. 2006. “Structural determinants for functional coupling between the b and a subunits in the Ca2+-activated K+ (BK) channel”. The Journal of General Physiology (JGP). Vol. 127 (2): 191 – 204. PMID: 16446507.